- eltrombopag用于循环障碍，因为硫酸镁可以降低血液中的浓度，从而降低血液中的浓度;
- 罗库溴铵用于手术期间的麻醉，因为它可以导致一个过度减少的随意肌肉（神经肌肉阻滞）和严重呼吸障碍（呼吸抑制，呼吸暂停）的收缩;
- 拉贝洛尔用于心跳节律紊乱，可明显减少心脏活动（心动过缓），减少从心脏泵出的血液量（心输出量），导致喘息，头晕和暂时丧失意识（昏厥）;
- 用于治疗高血压的药物（钙拮抗剂如isradipine，非洛地平，尼卡地平和硝苯地平），因为人们可以表现出血压过度降低（低血压）。
怀孕和哺乳
如果您怀孕了，如果您怀疑或计划怀孕，或母乳喂养，请在给您服药之前咨询医生。
怀孕
如果您怀孕了，该药只应在绝对必要的情况下给予并且必须在医生的直接控制下进行，该医生必须监测您宝宝的心脏活动（胎心率）（参见“警告和预防措施”）。
事实上，如果您患有一种名为妊娠毒血症的疾病，并且该药用于控制分娩前的癫痫发作，您的孩子可能会出现严重的肌肉和呼吸问题（神经肌肉和呼吸抑制）。
在交货前2小时，不应向您提供硫酸镁MONICO。喂养时间如果您正在哺乳，应该在直接呼吸医生检查下给您这种药。驾驶和使用机器没有关于驾驶和使用机器的数据。因此，如果您需要驾驶或使用机器，请询问您的医生。
3。如何使用MAGNESIUM SOLFATO MONICO
该药将由医生或专业人员在适当稀释后（使用5％葡萄糖或0.9％氯化钠溶液）给予您。对于可能形成的沉淀物，硫酸镁不应与含有以下物质的溶液混合：高浓度的醇，重金属，碳酸盐和碳酸氢盐
氢化可的松，琥珀酸钠，磷酸盐，硫酸多粘菌素B，盐酸普鲁卡因，水杨酸钙，克林霉素磷酸盐，酒石酸盐。
潜在的不相容性通常受到试剂浓度和溶液pH的改变的影响。应通过一次连续手术给药给您，并且必须消除任何残留物。
在严重妊娠毒血症的情况下预防和控制癫痫发作缺镁的治疗，特别是如果伴有手足搐,,在这些情况下，在治疗开始时，总剂量为10-14克硫酸镁。为了控制癫痫发作，必须在血液中达到一定量的镁（6mg / 100ml）。一天（24小时）内不应超过30-40克。
预防和治疗接受营养全胃肠外营养的人的镁缺乏症推荐剂量范围为每天1克至3克（8-24毫克当量）硫酸镁（24小时）。用于有肾脏问题的人如果您患有肾功能问题（严重肾功能衰竭），硫酸镁的最大剂量为每2天（48小时）20克。
如果您使用更多的MAGNESIO SULPHATE MONICO，医生或专业人员会给您这种药物，因此不太可能注射过量。但是，如果您认为它是由过多的MAGNESIO SULPHATE MONIC管理，请立即通知医生或其他健康专业人员。
服用过量的该药后，可能会出现毒性迹象，如：血压过高（血压峰值）和呼吸停止（呼吸麻痹）。
如果您对使用MAGNESIO SOLFATO MONICO有任何疑问，请咨询您的医生或护士。
4。可能的副作用
与所有药物一样，这种药可能会引起副作用，但并非所有人都能表现出副作用。可能发生以下不良反应： - 肠道紊乱（麻痹性肠梗阻，肠道转运延迟）; - 过敏反应（荨麻疹等过敏反应）; - 增加血液中酸性物质的水平（代谢性酸中毒）或降低血液中钙的含量（低钙血症）; - 突然感觉到热（潮红），出汗，降低血压（低血压），丧失自主运动（弛缓性麻痹），降低
5。 如何储存MAGNESIUM SOLFATO MONICO
让药物远离儿童的视线和触及范围。 在“EXP。”之后的包装上注明的有效期后，请勿使用该药。 到期日是指该月的最后一天以及包装中的产品完整且妥善存储。 将药物储存在原包装中。 不需要特定的储存温度。 应在小瓶/小瓶打开后立即通过单次和不间断给药给药，并且只有在溶液呈现清澈，无色且无颗粒的情况下才应给药。 必须删除任何剩余的药品。 不要通过废水或生活垃圾丢弃任何药物。 询问药剂师如何消除不再使用的药物。 这将有助于保护环境
What is MAGNESIUM SOLFATO MONICO and what it is used for
MAGNESIUM SULPHATE MONICO contains the active ingredient magnesium sulfate which is a salt of magnesium. Magnesium plays an essential role in the transmission of nerve impulses e in the contraction of muscles. This medicine is indicated for: - prevention and control of convulsions that may occur during the pregnancy if you suffer from a disease called pregnancy toxemia (pre-eclampsia, eclampsia), characterized by high blood pressure, swelling due to an accumulation of liquids (edema) and the presence of proteins in the urine; - provide the magnesium organism in cases where it is deficient and reaches low levels in blood (acute hypomagnesaemia), especially if you suffer from a disease characterized by cramps and spasms of the muscles (tetany); - prevention and treatment of the lowering of magnesium levels in the blood (hypomagnesemia), during direct administration into a nutrient vein (nutrition total parenteral).
2. What you need to know before using MAGNESIUM SOLFATO MONICO
Do not use MAGNESIUM SOLFATO MONICO
- if you are allergic to magnesium sulphate or any of the other ingredients of this medicinal product (listed in paragraph 6);
- if you suffer from heart problems (damage to the myocardium) or irregular heartbeat (cardiac arrhythmias);
- if you have severe kidney problems (severe renal impairment) (See section "Warnings and precautions"). Warnings and precautions Talk to your doctor or nurse before using MAGNESIO SOLFATO MONICO.
MAGNESIUM SULPHATE MONICO should only be given if the vial or the vial do not show damage and if the solution is clear. The medicine must be injected through a single and uninterrupted administration, at a controlled rate, after appropriate dilution. Any remaining medicinal product should be discarded (See paragraph "How to use MAGNESIUM SOLFATO MONICO").
During treatment with MAGNESIO SOLFATO MONICO the doctor must check periodically levels the magnesium in the blood, to prevent them from increasing excessively. MAGNESIUM SOLFATO MONICO must be given to you with particular caution if:
- suffers from kidney problems (renal impairment of less severe degree);
- is suffering from a serious muscle disease (myasthenia gravis). This medicine should not be given to you if you suffer from severe kidney problems (renal failure), because, following direct administration into a vein (intravenous), excessive magnesium levels in the blood may occur (magnesium intoxication) (See the section "Do not use MAGNESIUM SULPHATE MONICO ").
If you are pregnant and suffer from eclampsia, you will be given the medicine directly in the vein just to control seizures that can be fatal (See the paragraph "Pregnancy and lactation").
Other medicines and MAGNESIUM SOLFATO MONICO
Tell your doctor if you are using, have recently used or could use any other medicine. Take special care and talk to your doctor if you are taking:
- medicines that reduce brain activity (such as barbiturates, narcotics, other hypnotics, systemic anesthetics), as it is necessary to modify the dose of MAGNESIO SULPHATE MONICO to be administered to avoid further reduction of brain activity;
- medicines used for some heart problems (cardiac glycosides such as digitalis), in how much serious disturbances of the heartbeat can occur (modifications of the cardiac conduction);
- medicines that reduce muscle contraction (neuromuscular plaque blockers competitive and depolarizing), used before surgery, as the magnesium sulfate can enhance its effects
- some medicines used to treat infections caused by bacteria (antibiotics aminoglycosides), as they can enhance muscle relaxation (blockage neuromuscular), induced by magnesium;
- eltrombopag used for circulatory disorders, as magnesium sulphate can reduce the concentration in the blood, and therefore the effects;
- rocuronium used for anesthesia during surgery, because it can cause one excessive reduction of the contraction of the voluntary muscles (neuromuscular block) e severe breathing disorders (respiratory depression, apnea);
- labetalol used for disorders of the rhythm of the heartbeat, as can be manifest reduction of heart activity (bradycardia) and reduction in the volume of blood pumped from the heart (cardiac output) resulting in wheezing, dizziness and temporary loss of consciousness (fainting);
- medicines used for the treatment of high blood pressure (calcium antagonists as isradipine, felodipine, nicardipine and nifedipine), because one can manifest a excessive lowering of blood pressure (hypotension).
Pregnancy and breastfeeding
If you are pregnant, if you suspect or are planning to become pregnant, or are breast-feeding with breast milk ask your doctor for advice before you are given this medicine.
Pregnancy
If you are pregnant, this medicine should only be given in cases of absolute necessity and under the direct control of the doctor who must monitor the activity of the heart of your baby (fetal heart rate) (See the "Warnings e precautions ").
In fact, if you suffer from a disease called pregnancy toxemia and this medicine comes to you administered to control seizures before childbirth, your child may manifest severe muscle and breathing problems (neuromuscular and respiratory depression).
MAGNESIUM SULPHATE MONICO should not be given to you 2 hours before delivery. Feeding time If you are breast-feeding, this medicine should be given to you under the direct breath doctor's check. Driving and using machines There are no data on the ability to drive and use machines. Therefore, ask your doctor if you need to drive or use machinery.
3. How to use MAGNESIUM SOLFATO MONICO
This medicine will be given to you by a doctor or by specialized personnel afterwards appropriate dilution (with 5% glucose or 0.9% sodium chloride solution). For the possible formation of precipitates, magnesium sulphate should not be mixed with solutions containing: alcohol at high concentrations, heavy metals, carbonates and bicarbonates
sodium hydrocortisone, succinate, phosphates, polymyxin B sulfate, procaine hydrochloride, salicylate calcium, clindamycin phosphate, tartrates.
The potential incompatibility is often influenced from the modification of the reagent concentration and the pH of the solutions. The medicine should be given to you through one single continuous operation administration and any residual must be eliminated.
Prevention and control of seizures in case of severe pregnancy toxemia Treatment of magnesium deficiency, especially if accompanied by tetany In these cases, at the start of treatment, the total dose is 10-14 g of magnesium sulfate. To control seizures, it is necessary to reach a certain amount of magnesium in the blood (6 mg / 100 ml). You should not be given more than 30-40 g in one day (24 hours).
Prevention and treatment of magnesium deficiency in people receiving nutrition total parenteral The recommended dose ranges from 1 g to 3 g (8-24 mEq) of magnesium sulfate per day (24 hours). Use in people with kidney problems If you suffer from kidney function problems (severe renal failure), the maximum dose of magnesium sulfate is 20 g every 2 days (48 hours).
If you use more MAGNESIO SULPHATE MONICO than you should This medicine will be given to you by a doctor or specialist personnel, therefore it is unlikely that an overdose will be injected. However, if you think it was administered too much MAGNESIO SULPHATE MONIC, inform immediately the doctor or another health professional.
Following the administration of an overdose of this medicine, it is possible show signs of toxicity such as: excessive increase in blood pressure (peak of blood pressure) and stop breathing (respiratory paralysis).
If you have any further questions on the use of MAGNESIO SOLFATO MONICO, ask your doctor or nurse.
4. Possible side effects
Like all medicines, this medicine can cause side effects, although not all of them people manifest them. The following undesirable effects may occur: - disorders of the intestine (paralytic ileus, delayed intestinal transit); - allergic reactions (hypersensitivity reactions such as hives); - increase in levels of acidic substances in the blood (metabolic acidosis) or reduction of levels of calcium in the blood (hypocalcemia); - sudden sensation of heat (flushing), sweating, lowering of the pressure of the blood (hypotension), loss of voluntary motility (flaccid paralysis), lowering
5. How to store MAGNESIUM SOLFATO MONICO
Keep this medicine out of the sight and reach of children. Do not use this medicine after the expiry date which is stated on the pack after "EXP.". The expiry date refers to the last day of that month and to the product in packaging intact and properly stored. Store this medicine in the original package. No particular storage temperatures are required. The medicine should be administered immediately after the opening of the vial / vial through a single and uninterrupted administration and only if the solution is it presents limpid, colorless and free of particles. Any remaining medicinal product must be deleted. Do not throw away any medicines via wastewater or household waste. Ask the pharmacist how to eliminate the medicines you no longer use. This will help protect the environment
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详细处方信息以本药内容附件PDF文件（2018102818534734.PDF）的“原文Priscribing Information”为准
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