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  药店国别: 意大利药房
产地国家: 意大利
所属类别: 心血管系统药物->抗心绞痛药物
处方药:处方药
包装规格: 20毫克/10毫升/瓶
计价单位:
  点击放大  
生产厂家中文参考译名:
葛兰素史克 (意大利)
生产厂家英文名:
Glaxo group (Italy)
该药品相关信息网址1:
http://www.integrilin.com
该药品相关信息网址2:
http://www.drugs.com/integrilin.html
该药品相关信息网址3:
http://www.rxlist.com/integrilin-drug.htm
原产地英文商品名:
INTEGRILIN 20mg/10mls/vial
原产地英文药品名:
EPTIFIBATIDE
原产地英文化合物名称:
L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-a-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1->6)-disulfide
中文参考商品译名:
INTEGRILIN 20毫克/10毫升/瓶
中文参考药品译名:
依菲巴特
原产地国家批准上市年份:
1998/05/18
英文适应病症1:
Acute coronary syndrome
英文适应病症2:
Unstable angina
英文适应病症3:
No Q wave myocardial infarction
英文适应病症4:
Percutaneous coronary intervention therapy
英文适应病症5:
Angioplasty or arterial plaque excision
临床试验期:
完成
中文适应病症参考翻译1:
急性冠脉综合征
中文适应病症参考翻译2:
不稳定型心绞痛
中文适应病症参考翻译3:
无Q波心肌梗塞
中文适应病症参考翻译4:
经皮冠脉介入疗法
中文适应病症参考翻译5:
血管成形术或动脉粥样斑块切除术
药品信息:

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 详细处方信息以本药内容附件PDF文件(201011922485237.pdf)的“原文Priscribing Information”为准
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部分中文依菲巴特处方资料(仅供参考)

   
    Integrilin现在适用于药物治疗或PCI治疗的急性冠脉综合症患者以及PCI术中的患者,后者包括进行冠脉内放置支架的患者。
    新疗法是以ESPRIT试验资料为基础的。两家公司在联合声明中说,该试验表明三种剂量的疗法可显著降低心脏病、急性靶血管的血管再形成和死亡的发生率。该试验还表明三种剂量的疗法可减少PCI过程中取出血栓的必要性。这大大减少了副作用的发生。其具体使用方法为,首先以180 mcg/kg的大剂量注射Integrilin,随后立即以每分钟2.0 mcg/kg的剂量灌注,10分钟后再次以180 mcg/kg的大剂量注射。
    据此,Integrilin的说明书也做了更改,认为肾功不全的患者应减小剂量,接受PCI的患者的肝素使用剂量也应进行调整,并补充了其它一些安全注意事项。

英文名称: Eftifibatide

英文别名: Eptifibatide; Integrelin; Integrilin; Intrifiban;L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-a-aspartyl-L-tryptophyl-L-prolyl-, cyclic (1->6)-disulfide

中文名称: 依菲巴特

中文别名: 依非巴特;埃替非巴肽;安普利肽

药理毒理: 利用枸橼酸盐抗凝剂评价,本品抑制血小板聚焦作用较其它非螯合型抗凝剂强 2 ~ 4 倍。本品可使急性冠脉综合征病人及进行 PCI 术病人的出血时间延长 2 ~ 4 倍(与其基线值相比),在停止输注本品后 1 小时内恢复正常。 本品经大鼠、兔和猴的安全性评价试验,未见毒性反应的迹象,给猴连续静脉输注 28 天,每天剂量高达 7.2mg/kg 也未见毒性表现。

适应症: 本品适用于治疗急性冠脉综合征,包括不稳定型心绞痛或无Q波心肌梗塞(既24小时内胸痛持续发作、心电图改变和/或心血管系统酶升高);也可用于经皮冠脉介入疗法,包括血管成形术或动脉粥样斑块切除术。一般不用于无急性冠脉综合征的血管成形术。在专人监管下,本品可与阿司匹林或肝素辅用。
 
Integrilin
Generic Name: eptifibatide (ep ti FYE ba tide)
Brand Names: Integrilin

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What is Integrilin?
Integrilin keeps the platelets in your blood from coagulating (clotting) to prevent unwanted blood clots that can occur with certain heart or blood vessel conditions.

Integrilin is used to prevent blood clots or heart attack in people with severe chest pain or other conditions, and in those who are undergoing a procedure called angioplasty (to open blocked arteries).

Integrilin may also be used for purposes other than those listed in this medication guide.

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Important information about Integrilin
Do not receive Integrilin if you are allergic to eptifibatide, or to similar drugs such as abciximab (ReoPro) or tirofiban (Aggrastat).

Do not receive Integrilin if you have a stomach ulcer or ulcerative colitis, severe liver disease, severe high blood pressure, a bleeding or blood clotting disorder, a history of head injury, brain tumor, or blood clot in the brain (aneurysm), a stroke or any type of bleeding within the past 30 days, or any type of surgery, injury, or medical emergency within the past 6 weeks.

Integrilin is not expected to be harmful to an unborn baby. However, aspirin is sometimes given with Integrilin, and aspirin can cause bleeding when it is taken during the last 3 months of pregnancy. Aspirin can also cause side effects in a newborn baby.
Tell your doctor if you are pregnant or plan to become pregnant during treatment with Integrilin and aspirin.

Because Integrilin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

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Before receiving Integrilin
Do not receive Integrilin if you are allergic to eptifibatide, if you have or will soon receive treatment with similar medications such as abciximab (ReoPro) or tirofiban (Aggrastat), or if you have:
kidney disease (or if you are on dialysis);
a severe form of hypertension (high blood pressure);
a bleeding or blood clotting disorder, such as hemophilia or thrombocytopenia;
a history of blood clot in the brain (aneurysm);
if you have had a stroke or any type of bleeding within the past 30 days; or
if you have had any type of surgery, injury, or medical emergency within the past 6 weeks.

Before using Integrilin, tell your doctor if you are allergic to any drugs

FDA Pregnancy Category B. Integrilin is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Integrilin passes into breast milk or if it could harm a nursing baby. Do not receive Integrilin without telling your doctor if you are breast-feeding a baby.

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How is Integrilin given?
Integrilin is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting.

If you are receiving this injection during an angioplasty procedure, the medicine will be given throughout the entire procedure and for up to 24 hours after the procedure.

Integrilin is usually given continuously for up to 4 days.

Integrilin is sometimes given together with aspirin.

To be sure Integrilin is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Because Integrilin keeps your blood from coagulating (clotting) to prevent unwanted blood clots, it can also make it easier for you to bleed, even from a minor injury. Contact your doctor or seek emergency medical attention if you have bleeding that will not stop.

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What happens if I miss a dose?
Since Integrilin is usually given in a hospital or clinic setting as needed, it is not likely that you will miss a dose.

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What happens if I overdose?
Seek emergency medical attention if you think you have received too much of this medicine.
Symptoms of an Integrilin overdose may include severe bleeding.

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What should I avoid while receiving Integrilin?
Integrilin lowers blood cells that help your blood clot. This can make it easier for you to bruise or bleed from an injury or minor cut. Avoid activities that increase your risk of a bruising or bleeding injury. Use extra caution to avoid cuts when brushing your teeth or shaving.

Avoid drinking alcohol while receiving Integrilin. Alcohol may increase your risk of bleeding in your stomach or intestines.

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Integrilin side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:
nosebleed or other bleeding that will not stop;
black, bloody, or tarry stools;
coughing up blood or vomit that looks like coffee grounds;
feeling light-headed, fainting;
sudden numbness or weakness, especially on one side of the body;
sudden headache, confusion, problems with vision, speech, or balance;
fever, chills, body aches, flu symptoms; or
pale skin, easy bruising or bleeding, weakness, fever, and urinating more or less than usual.

Less serious side effects may also occur, such as:
nausea, stomach pain;
runny or stuffy nose, cough, sore throat; or
mild headache or dizziness.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

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What other drugs will affect Integrilin?
Before receiving Integrilin, tell your doctor if you are using any of the following drugs:
a blood thinner such as warfarin (Coumadin), heparin, ardeparin (Normiflo), dalteparin (Fragmin), danaparoid (Orgaran), enoxaparin (Lovenox), or tinzaparin (Innohep); or
any other medications used to prevent blood clots, such as alteplase (Activase), anistreplase (Eminase), clopidogrel (Plavix), dipyridamole (Persantine), streptokinase (Kabikinase, Streptase), ticlopidine (Ticlid), or urokinase (Abbokinase).

If you are using any of these drugs, you may not be able to receive Integrilin, or you may need dosage adjustments or special tests during treatment.

There may be other drugs not listed that can affect Integrilin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Where can I get more information?
Your pharmacist has information about Integrilin written for health professionals that you may read.

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What does my medication look like?
Eptifibatide is available with a prescription under the brand name Integrilin. Other brand or generic formulations may also be available. Ask your pharmacist any questions you have about Integrilin, especially if it is new to you.

Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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 详细处方信息以本药内容附件PDF文件(201011922485237.pdf)的“原文Priscribing Information”为准
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更新日期: 2017-09-27
附件:
 
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